5-羟色胺4（5HT4）激动剂可抑制干扰素-γ诱导培养星形胶质细胞上的II类主要组织相容性复合体（MHC）和B7共刺激分子的表达。
5HT4 agonists inhibit interferon-gamma-induced MHC class II and B7 costimulatory molecules expression on cultured astrocytes.
作者信息
Zeinstra Esther M, Wilczak Nadine, Wilschut Jan C, Glazenburg Lisa, Chesik Daniel, Kroese Frans G M, De Keyser Jacques
机构信息
Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands.
出版信息
J Neuroimmunol. 2006 Oct;179(1-2):191-5. doi: 10.1016/j.jneuroim.2006.06.012. Epub 2006 Jul 12.
A failure of tight control of MHC class II expression on astrocytes may play a role in the development of autoimmune responses in multiple sclerosis. The 5-HT(4) serotonin receptor agonists cisapride and prucalopride, at concentrations between 10(-10) M and 10(-8) M, reduced interferon-gamma-induced MHC class II immunostaining in cultured astrocytes derived from newborn Wistar rats by approximately 50-60%. The magnitude of MHC class II inhibition by 5-HT(4) agonists was comparable to that of interferon-beta. The alpha(1)-adrenergic receptor agonist phenylephrine was without effect. Cisapride (10(-9) M) also prevented interferon-gamma-induced B7-1 and B7-2 immunostaining. Our results suggest that 5-HT(4) agonists may have therapeutic potential in multiple sclerosis by inhibiting the up-regulation of immune responsiveness of astrocytes in the central nervous system.
星形胶质细胞上主要组织相容性复合体II类（MHC II）表达的严格调控失败可能在多发性硬化症自身免疫反应的发展中起作用。5-羟色胺（5-HT）4受体激动剂西沙必利和普芦卡必利在10^(-10) M至10^(-8) M的浓度下，可使新生Wistar大鼠培养的星形胶质细胞中干扰素-γ诱导的MHC II免疫染色减少约50%-60%。5-HT4激动剂对MHC II的抑制程度与干扰素-β相当。α1-肾上腺素能受体激动剂去氧肾上腺素无此作用。西沙必利（10^(-9) M）也可阻止干扰素-γ诱导的B7-1和B7-2免疫染色。我们的结果表明，5-HT4激动剂可能通过抑制中枢神经系统星形胶质细胞免疫反应性的上调而在多发性硬化症中具有治疗潜力。
Zotero 插件