Tontsch U, Rott O
Department of Neuroimmunology, Max-Planck Institute for Psychiatry, Martinsried, Germany.
Immunology. 1993 Nov;80(3):507-9.
We have studied the effect of rat central nervous system (CNS) neurons on the inducibility of major histocompatibility complex (MHC) class I molecules on syngeneic astrocytes. In a co-culture system composed of embryonic rat cortical neurons and neonatal astrocytes, intact neurons decreased constitutive expression of MHC class I determinants and inhibited the induction of class I products on astrocytes. Viability of the neurons and direct contact with astrocytes was critical for this effect. Soluble factors released by neurons were inefficient. Our data indicate that the lack of MHC class I expression on astrocytes in situ might be the result of an active suppression mechanism rather than merely due to the absence of activating factors in the CNS.
我们研究了大鼠中枢神经系统（CNS）神经元对同基因星形胶质细胞上主要组织相容性复合体（MHC）I类分子诱导性的影响。在由胚胎大鼠皮质神经元和新生星形胶质细胞组成的共培养系统中，完整的神经元降低了MHC I类决定簇的组成性表达，并抑制了星形胶质细胞上I类产物的诱导。神经元的活力以及与星形胶质细胞的直接接触对这种效应至关重要。神经元释放的可溶性因子作用效率低下。我们的数据表明，原位星形胶质细胞上缺乏MHC I类表达可能是一种主动抑制机制的结果，而不仅仅是由于中枢神经系统中缺乏激活因子。
