Mellor Jane
Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK.
Cell. 2006 Jul 14;126(1):22-4. doi: 10.1016/j.cell.2006.06.028.
The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression through interactions with trimethylated lysine 4 on histone 3 (H3K4), a universal modification at the beginning of active genes.
被称为组蛋白密码的组蛋白修饰模式，影响着染色质状态之间的转变以及转录活性的调控。最近的四篇论文描述了植物同源异型域（PHD）指蛋白是如何解读这一密码的部分内容的。PHD指蛋白可能通过与组蛋白3上的三甲基化赖氨酸4（H3K4）相互作用，促进基因表达和抑制，H3K4是活跃基因起始处的一种普遍修饰。
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