Pizzimenti Joseph J, Nickerson Maritza M, Pizzimenti Claire E, Kasten-Aker Ann G
Nova Southeastern University, College of Optometry, Ft. Lauderdale, Florida 33328-2018, USA.
Optom Vis Sci. 2006 Jul;83(7):421-5. doi: 10.1097/01.opx.0000225106.52653.72.
Intravitreal injection of triamcinolone acetonide has increasingly become a therapeutic option for neovascular, inflammatory, and edematous intraocular diseases. A common side effect of this treatment is a steroid-induced elevation of intraocular pressure. In most of these patients, the rise in intraocular pressure can be treated topically. Those cases that cannot be treated medically have been treated with filtering surgery. This report presents a case of intraocular pressure elevation after intravitreal triamcinolone acetonide injection that was successfully treated with selective laser trabeculoplasty.
A 63-year-old white man presented with brow ache on the right side approximately 3 months after undergoing intravitreal injection of triamcinolone acetonide for diabetic macular edema in the right eye. Applanation tonometry revealed an intraocular pressure of 45 mm Hg in the involved eye. After initial treatment with topical medications, the patient underwent selective laser trabeculoplasty. Now, 6 months postlaser treatment, the intraocular pressure in the involved eye is stable at 15 mm Hg without topical medications.
A steroid-induced elevation of intraocular pressure is a common and widely reported side effect of treatment with intravitreal triamcinolone acetonide. This case report suggests that selective laser trabeculoplasty has potential as first- or second-line therapy for intraocular pressure elevation after intravitreal triamcinolone acetonide injection.
玻璃体内注射曲安奈德已日益成为治疗新生血管性、炎症性和水肿性眼内疾病的一种治疗选择。这种治疗的常见副作用是类固醇诱导的眼压升高。在大多数这类患者中,眼压升高可用局部治疗。那些无法通过药物治疗的病例已采用滤过性手术治疗。本报告介绍了一例玻璃体内注射曲安奈德后眼压升高的病例,该病例通过选择性激光小梁成形术成功治疗。
一名63岁白人男性,右眼因糖尿病性黄斑水肿接受玻璃体内注射曲安奈德约3个月后出现右侧眉部疼痛。压平眼压测量显示患眼眼压为45毫米汞柱。在用局部药物进行初始治疗后,患者接受了选择性激光小梁成形术。现在,激光治疗6个月后,患眼眼压在未使用局部药物的情况下稳定在15毫米汞柱。
类固醇诱导的眼压升高是玻璃体内注射曲安奈德治疗常见且广泛报道的副作用。本病例报告表明,选择性激光小梁成形术有潜力作为玻璃体内注射曲安奈德后眼压升高的一线或二线治疗方法。