Klein O, Freppel S, Schuhmacher H, Pinelli C, Auque J, Marchal J-C
Département de Neurochirurgie, Hôpital Central, CHU, 29, avenue Maréchal-de-Lattre-de-Tassigny, 54035 Nancy Cedex.
Neurochirurgie. 2006 Jun;52(2-3 Pt 1):111-8. doi: 10.1016/s0028-3770(06)71205-x.
We report a series of five subdural empyema (SDE) in children and young adults treated in the same neurosurgical department. These five cases were reviewed retrospectively. There were four boys and one girl, aged from three months to 18 years at time of diagnosis (median age: 7 years). SDE following intracranial surgery were excluded from the study. All patients were treated surgically (burr hole evacuation or craniotomy, repeated in some cases), followed by intravenous antibiotic therapy (mean time: 52 days) adapted to the micro-organism. Only the two patients treated by large craniotomy at first had a single surgical procedure. Involved micro-organisms are as follow: Streptococcus intermedius (n=2), Streptococcus pneumoniae (n=1), Escherichia coli (n=1), absence of any identified micro-organism (n=1). The five patients are alive (median follow-up: 22 month) without any sequelae. We advocate an aggressive surgical treatment of SDE in children with a large bone flap to allow the surgeon to remove pus and membranes as much as possible, even in the interhemispheric fissure, followed by intravenous appropriate antibiotherapy and eradication of the source of infection. Even this "aggressive" treatment may sometimes not avoid re-operation. A careful follow-up is mandatory, because of the high risk of recurrence.
我们报告了同一神经外科治疗的一系列5例儿童和青年成人的硬脑膜下积脓(SDE)病例。对这5例病例进行了回顾性分析。有4名男孩和1名女孩,诊断时年龄从3个月至18岁(中位年龄:7岁)。颅内手术后发生的SDE被排除在本研究之外。所有患者均接受了手术治疗(钻孔引流或开颅手术,部分病例进行了重复手术),随后根据微生物情况进行静脉抗生素治疗(平均时间:52天)。只有最初接受大骨瓣开颅手术的2例患者进行了单次手术。涉及的微生物如下:中间链球菌(n = 2)、肺炎链球菌(n = 1)、大肠杆菌(n = 1)、未发现任何微生物(n = 1)。5例患者均存活(中位随访时间:22个月),无任何后遗症。我们主张对儿童SDE进行积极的手术治疗,采用大骨瓣开颅,以便外科医生尽可能多地清除脓液和包膜,即使在大脑半球间裂也如此,随后进行静脉适当的抗生素治疗并根除感染源。即使这种“积极”治疗有时也可能无法避免再次手术。由于复发风险高,必须进行仔细的随访。