ω-芋螺毒素GVIA对小鼠神经肌肉接头处神经递质释放的影响。
Effect of omega-conotoxin GVIA on neurotransmitter release at the mouse neuromuscular junction.
作者信息
Protti D A, Szczupak L, Scornik F S, Uchitel O D
机构信息
Instituto de Biologia Celular, Facultad de Medicina, U.B.A., Argentina.
出版信息
Brain Res. 1991 Aug 23;557(1-2):336-9. doi: 10.1016/0006-8993(91)90156-p.
The effect of omega-conotoxin GVIA (omega-CgTx) was studied on spontaneous, K(+)-induced and electrically evoked neurotransmitter release at the neuromuscular junction of mouse diaphragm. omega-CgTx decreased the frequency and amplitude of basal and K(+)-induced miniature end plate potentials. This effect was abolished by raising the extracellular Ca2+ concentration. omega-CgTx had no effect on the quantal content of the electrically evoked release in this preparation.
研究了ω-芋螺毒素GVIA（ω-CgTx）对小鼠膈肌神经肌肉接头处自发性、钾离子诱导性及电诱发的神经递质释放的影响。ω-CgTx降低了基础及钾离子诱导的微小终板电位的频率和幅度。提高细胞外钙离子浓度可消除该效应。在该实验制剂中，ω-CgTx对电诱发释放的量子含量没有影响。
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