Mansfield C S, Mooney C T
Department of Small Animal Clinical Studies, Faculty of Veterinary Medicine, University College Dublin, Belfield, Ireland.
J Small Anim Pract. 2006 Jul;47(7):396-9. doi: 10.1111/j.1748-5827.2006.00047.x.
An 18-month-old boxer was presented for investigation of profound lethargy, and primary hypothyroidism was diagnosed. A strong antithyroglobulin antibody titre was also present, indicating lymphocytic (immune-mediated) thyroiditis as the cause of hypothyroidism. A concurrent protein-losing glomerulonephropathy was also detected, although the aetiology could not be determined at initial presentation. Thyroid replacement and dietary therapy were prescribed. The dog improved clinically for approximately 12 months when it was re-presented with poorly controlled hypothyroidism and renal failure. Postmortem examination confirmed the presence of lymphocytic-plasmacytic thyroiditis, in conjunction with membranoproliferative glomerulonephritis and renal failure.
一只18个月大的拳师犬因极度嗜睡前来检查，被诊断为原发性甲状腺功能减退。同时还检测到抗甲状腺球蛋白抗体滴度很高，提示淋巴细胞性（免疫介导）甲状腺炎是甲状腺功能减退的病因。尽管在初次就诊时无法确定病因，但同时也检测到了并发的蛋白丢失性肾小球肾炎。给予了甲状腺替代治疗和饮食疗法。这只狗临床症状改善了大约12个月，之后再次出现甲状腺功能减退控制不佳和肾衰竭的情况。尸检证实存在淋巴细胞-浆细胞性甲状腺炎，同时伴有膜增生性肾小球肾炎和肾衰竭。
