Song L, Bai Y, Guo Z, Dai W, Cui Q
PUMC Hospital, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1997 Aug;19(4):263-7.
There have been many reports on the incidence of hypothyroidism and thyroid carcinoma in chronic lymphocytic thyroiditis patients, however, the incidence of thyroid carcinoma had been a widely debated issue. Therefore 300 cases of chronic lymphocytic thyroiditis from 1964 to 1995 were reviewed. There were 37 males and 263 females, and 52 had a pathological diagnosis of chronic lymphocytic thyroiditis.
Among 300 patients, 2 had coexistent thyroid papillary carcinoma. The original symptom in 64.3% patients was hypothyroidism, and the total incidence of hypothyroidism was 76%. It was also indicated in this study that the occurrence of hypothyroidism in chronic lymphocytic thyroiditis patient was associated with the elevated level of antithyroglobulin antibody, enlargement and tenderness of thyroid gland.
In our study, as the low incidence of coexisted thyroid carcinoma, with the high incidence of hypothyroidism it seemed to be that the elevated antithyroglobulin antibody could be a more effective factor in the development of hypothyroidism in chronic lymphocytic thyroiditis.
关于慢性淋巴细胞性甲状腺炎患者甲状腺功能减退症及甲状腺癌的发病率已有诸多报道，然而，甲状腺癌的发病率一直是一个备受争议的问题。因此，对1964年至1995年间的300例慢性淋巴细胞性甲状腺炎患者进行了回顾性研究。其中男性37例，女性263例，52例有慢性淋巴细胞性甲状腺炎的病理诊断。
300例患者中，2例合并甲状腺乳头状癌。64.3%的患者最初症状为甲状腺功能减退症，甲状腺功能减退症的总发生率为76%。本研究还表明，慢性淋巴细胞性甲状腺炎患者甲状腺功能减退症的发生与抗甲状腺球蛋白抗体水平升高、甲状腺肿大及压痛有关。
在我们的研究中，由于合并甲状腺癌的发生率较低，而甲状腺功能减退症的发生率较高，似乎抗甲状腺球蛋白抗体水平升高可能是慢性淋巴细胞性甲状腺炎患者发生甲状腺功能减退症的一个更有效的因素。
