Boddy Alan V
Northern Institute for Cancer Research, Medical School, University of Newcastle, Newcastle upon Tyne, UK.
Br J Clin Pharmacol. 2006 Jul;62(1):27-34. doi: 10.1111/j.1365-2125.2006.02714.x.
Advances in analytical methods, imaging techniques and an increased understanding of the influence of pharmacogenetic factors have added to our knowledge of the pharmacology of many chemotherapeutic agents. Extending the use of these approaches to pharmacodynamic end-points, together with the application of population-based modelling techniques, offers the potential to develop truly individualized therapy in the future.
分析方法、成像技术的进步以及对药物遗传学因素影响的深入理解,增加了我们对许多化疗药物药理学的认识。将这些方法扩展应用于药效学终点,并结合基于群体的建模技术,为未来开发真正的个体化治疗提供了潜力。