在对脑脊液强啡肽A和甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7进行研究后，未发现纤维肌痛患者存在内啡肽缺乏的证据。

No evidence for endorphin deficiency in fibromyalgia following investigation of cerebrospinal fluid (CSF) dynorphin A and Met-enkephalin-Arg6-Phe7.

作者信息

Vaerøy Henning, Nyberg Fred, Terenius Lars

机构信息

Department of Biological and Medical Psychology, University of Bergen, BergenNorway Department of Pharmaceutical Pharmacology, University of Uppsala, UppsalaSweden Department of Experimental Drug Dependence Research, Karolinska Institute, StockholmSweden.

出版信息

Pain. 1991 Aug;46(2):139-143. doi: 10.1016/0304-3959(91)90068-9.

DOI:10.1016/0304-3959(91)90068-9

PMID:1684241

Abstract

The CSF levels of Met-enkephalin-Arg6-Phe7 and dynorphin A were measured in patients with fibromyalgia. The mean CSF Met-enkephalin-Arg6-Phe7 level was 35.1 +/- 2.4 fmol/ml (mean +/- S.E.M.). The mean CSF level of dynorphin A was 14.3 +/- 0.9 fmol/ml. Regression analysis showed a statistically significant correlation between Met-enkephalin-Arg6-Phe7 and dynorphin A (r = 0.5369, P = 0.001). When correlated to the previously measured CSF levels of beta-endorphin, a statistically significant correlation was found with Met-enkephalin-Arg6-Phe7 (r = 0.5055, P = 0.03) but not with dynorphin A (P greater than 0.05). The Met-enkephalin-Arg6-Phe7 and dynorphin A levels are elevated compared to the levels available for comparison groups. Therefore, a lack of endorphin secretion does not seem to be the basis for the hyperalgesia observed in these patients.

摘要

对纤维肌痛患者的脑脊液中甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7（Met-enkephalin-Arg6-Phe7）和强啡肽A的水平进行了测量。脑脊液中甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7的平均水平为35.1±2.4飞摩尔/毫升（平均值±标准误）。强啡肽A的脑脊液平均水平为14.3±0.9飞摩尔/毫升。回归分析显示甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7与强啡肽A之间存在统计学显著相关性（r = 0.5369，P = 0.001）。当与先前测量的脑脊液β-内啡肽水平相关联时，发现与甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7存在统计学显著相关性（r = 0.5055，P = 0.03），但与强啡肽A不存在相关性（P＞0.05）。与对照组可比较的水平相比，甲硫氨酸脑啡肽-精氨酸6-苯丙氨酸7和强啡肽A的水平升高。因此，内啡肽分泌缺乏似乎不是这些患者中观察到的痛觉过敏的基础。