Cândido Ana Paula Carlos, Ferreira Silvania, Lima Angélica Alves, de Carvalho Nicolato Roney Luiz, de Freitas Sílvia Nascimento, Brandão Paulo, Pereira Alexandre, Krieger José Eduardo, do Nascimento-Neto Raimundo Marques, Machado-Coelho George Luiz Lins
Departamento de Farmácia, Universidade Federal de Ouro Preto, Rua Costa Sena 171, 35400-000 Ouro Preto, Minas Gerais, MG, Brazil.
Atherosclerosis. 2007 Apr;191(2):454-9. doi: 10.1016/j.atherosclerosis.2006.04.031. Epub 2006 Jul 14.
Evidences suggest that lipoprotein(a) [Lp(a)] is an important risk factor for cardiovascular disease. However, literature has been controversial in confirming its role as an independent risk factor for cardiovascular disease. The objective of the present study is to evaluate the association between serum levels of Lp(a) and ischemic heart disease as well as other cardiovascular risk factors in a population-based study conducted on a local cohort of the Brazilian population. Lp(a) serum levels were measured in 400 individuals selected from a larger sample of a populational survey carried out in Ouro Preto, a city in the southeast of Brazil. Lipid profile, fasting blood glucose, anthropometric and clinical parameters were analyzed. Lp(a) levels were significantly associated with the presence of ischemic heart disease. In relation to other cardiovascular risk factors, it was verified that Lp(a) levels were statistically associated with age, total cholesterol, LDL-cholesterol and percentage of body fat determined by bioelectric impedance. Lp(a) was also highly associated with the Framingham risk score (p=0.003). In a multivariate analysis two significant interactions were revealed; one involving ischemic heart disease, sex and age and other associating ischemic heart disease, age and total cholesterol. In summary, in the present analysis Lp(a) serum levels were correlated with the occurrence of ischemic heart disease and other cardiovascular risk factors.
有证据表明，脂蛋白(a)[Lp(a)]是心血管疾病的一个重要危险因素。然而，在确认其作为心血管疾病独立危险因素的作用方面，文献一直存在争议。本研究的目的是在一项针对巴西当地人群队列进行的基于人群的研究中，评估血清Lp(a)水平与缺血性心脏病以及其他心血管危险因素之间的关联。从巴西东南部城市欧鲁普雷图进行的一项大规模人群调查样本中选取400名个体，测量其血清Lp(a)水平。分析了血脂谱、空腹血糖、人体测量和临床参数。Lp(a)水平与缺血性心脏病的存在显著相关。关于其他心血管危险因素，经证实Lp(a)水平与年龄、总胆固醇、低密度脂蛋白胆固醇以及通过生物电阻抗测定的体脂百分比存在统计学关联。Lp(a)也与弗明汉风险评分高度相关(p = 0.003)。在多变量分析中发现了两个显著的相互作用；一个涉及缺血性心脏病、性别和年龄，另一个将缺血性心脏病、年龄和总胆固醇联系起来。总之，在本分析中，血清Lp(a)水平与缺血性心脏病的发生以及其他心血管危险因素相关。
