Widjaja E, Whitby E H, Cohen M, Paley M N J, Griffiths P D
Academic Section of Radiology, Sheffield Children's Hospital, Sheffield, UK.
Clin Radiol. 2006 Aug;61(8):679-85. doi: 10.1016/j.crad.2006.01.016.
To compare the findings of post-mortem magnetic resonance imaging (MRI) of the foetal spine with autopsy with a view to using post-mortem MRI as an alternative or adjunct to autopsy, particularly in foetal and neonatal cases.
The brains and spines of 41 foetuses, with a gestational age range of 14-41 weeks, underwent post-mortem MRI before autopsy. Post-mortem MRI of the brain consisted of T2-weighted sequences in three orthogonal planes and MRI of the spine consisted of T2-weighted sequence in the sagittal and axial planes in all cases and coronal planes in selected cases.
Thirty of 41 (78%) foetal spines were found to be normal at autopsy and on post-mortem MRI. Eleven of 41 (22%) foetal spines were abnormal: eight foetuses had myelomeningocoeles and Chiari 2 deformities, one foetus had limited dorsal myeloschisis, one foetus had caudal regression syndrome, and one had diastematomyelia. The post-mortem MRI findings concurred with the autopsy findings in 10/11 of the abnormal cases, the disagreement being the case of diastematomyelia that was shown on post-mortem MRI but was not diagnosed at autopsy.
In this series, post-mortem MRI findings agreed with the autopsy findings in 40/41(98%) cases and in one case the post-mortem MRI demonstrated an abnormality not demonstrated at autopsy.
比较胎儿脊柱的尸检磁共振成像（MRI）结果与尸检结果，以期将尸检MRI作为尸检的替代方法或辅助手段，尤其是在胎儿和新生儿病例中。
对41例孕周为14 - 41周的胎儿的脑和脊柱在尸检前进行了尸检MRI检查。脑部的尸检MRI包括三个正交平面的T2加权序列，脊柱的MRI在所有病例中包括矢状面和轴面的T2加权序列，在部分病例中还包括冠状面的T2加权序列。
41例胎儿中，30例（78%）在尸检和尸检MRI中显示脊柱正常。41例中有11例（22%）胎儿脊柱异常：8例胎儿患有脊髓脊膜膨出和Chiari 2畸形，1例胎儿患有局限性背侧脊髓裂，1例胎儿患有尾椎退化综合征，1例患有脊髓纵裂。11例异常病例中，10例的尸检MRI结果与尸检结果一致，不一致的情况是尸检MRI显示有脊髓纵裂，但尸检未诊断出该病变。
在本系列研究中，41例中有40例（98%）的尸检MRI结果与尸检结果一致，有1例尸检MRI显示出尸检未发现的异常。
