大环内酯类耐药性可通过接合作用从草绿色链球菌转移至化脓性链球菌。
Macrolide resistance can be transferred by conjugation from viridans streptococci to Streptococcus pyogenes.
作者信息
Jönsson Maria, Swedberg Göte
机构信息
Department of Medical Biochemistry and Microbiology, Uppsala University Biomedical Centre, Box 582, SE-751 23 Uppsala, Sweden.
出版信息
Int J Antimicrob Agents. 2006 Aug;28(2):101-3. doi: 10.1016/j.ijantimicag.2006.02.023. Epub 2006 Jul 14.
Efflux pumps encoded by mef genes are among the most common mechanisms of resistance to macrolides. These genes are often located on horizontally transferable elements such as transposons. We present data indicating conjugative transfer of the mef(E) gene from viridans streptococci to the pathogen Streptococcus pyogenes. The mef(E) gene is located on the previously described MEGA (macrolide efflux genetic assembly) element. Of 110 isolates tested, 85% of those that carried the mef(A/E) gene carried it on MEGA, and in all cases of conjugal transfer of the mef(E) gene it was carried on MEGA. It therefore appears reasonable to draw the conclusion that this element is important in the lateral transfer of macrolide resistance between streptococci.
由mef基因编码的外排泵是对大环内酯类耐药的最常见机制之一。这些基因通常位于可水平转移的元件上，如转座子。我们提供的数据表明mef(E)基因可从草绿色链球菌接合转移至病原体化脓性链球菌。mef(E)基因位于先前描述的MEGA（大环内酯外排基因组合体）元件上。在测试的110株分离株中，携带mef(A/E)基因的菌株中有85%是在MEGA元件上携带该基因，并且在mef(E)基因的所有接合转移案例中，它都是由MEGA元件携带。因此，得出这一元件在链球菌之间大环内酯类耐药性的横向转移中很重要这一结论似乎是合理的。
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