Campanella S, Montedoro C, Streel E, Verbanck P, Rosier V
CHU de Brugmann, Psychiatry Service, Site Victor Horta, place Arthur Van Gehuchten 4, B-1020 Brussels, Belgium.
Neurophysiol Clin. 2006 Mar-Apr;36(2):71-8. doi: 10.1016/j.neucli.2006.04.005. Epub 2006 May 17.
On the basis of the Positive and Negative Syndrome Scale (PANSS), fourteen schizophrenic patients and 7 normal controls were confronted with pictures from the Ekman & Friesen series in an event-related potentials study.
Participants were confronted with a visual face-detection task, in which they had to detect, as quickly as possible, deviant faces amongst a train of standard stimuli (neutral faces). Deviant faces changed either on identity (different identity, neutral expression), or on emotion (same identity, happy, fearful or sad expression).
Schizophrenics exhibited a decrease in amplitude of the face N170, recorded around 170 ms at occipito-temporal sites; this was observed as well for emotional as for identity faces, which suggests a global involvement of face processing. Moreover, this decrease of the face-N170 was positively correlated to positive, but not negative, symptoms of schizophrenia. Finally, the amplitude of P100 was also decreased, which suggests that the N170 decrement would result from a more global deficit in visual processing deficit.
It is suggested that, in schizophrenics, an involvement of early visual processing might underlie the decreased amplitudes and the higher onset latencies of later P300 and N400 components.
在阳性与阴性症状量表（PANSS）的基础上，14名精神分裂症患者和7名正常对照参与了一项事件相关电位研究，研究中他们面对的是埃克曼和弗里森系列图片。
参与者面对一项视觉面部检测任务，在一系列标准刺激（中性面部）中，他们必须尽快检测出异常面部。异常面部在身份（不同身份，中性表情）或情绪（相同身份，高兴、恐惧或悲伤表情）方面有所变化。
精神分裂症患者在枕颞部位记录到的面部N170波幅降低，在170毫秒左右出现；无论是情绪面部还是身份面部均观察到这种情况，这表明面部加工存在整体受累。此外，面部N170的这种降低与精神分裂症的阳性症状而非阴性症状呈正相关。最后，P100波幅也降低了，这表明N170降低可能是由于视觉加工存在更广泛的缺陷所致。
研究表明，在精神分裂症患者中，早期视觉加工受累可能是后期P300和N400成分波幅降低及起始潜伏期延长的基础。
