Fitzpatrick B, Ordoñez N G, Mackay B
Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Ultrastruct Pathol. 1991 Jul-Oct;15(4-5):579-84. doi: 10.3109/01913129109016266.
A case of islet cell tumor occurring in a patient with the multiple endocrine neoplasia type I syndrome is reported. Immunostaining for insulin was strongly positive in the tumor cells. Numerous dense-core granules of endocrine caliber were identified ultrastructurally. Morphometric analysis of the secretory granules in 20 islet cell tumors gave a granule size of 182 +/- 52 nm (mean +/- standard deviation).
