Waller E Andrew, Kaplan Joseph
Department of Internal Medicine, Mayo Clinic, Jacksonville, FL 32256, USA.
Compr Ther. 2006 Summer;32(2):94-101. doi: 10.1385/comp:32:2:94.
Pergolide is an ergot derivative dopamine agonist used in the treatment of Parkinson's disease and restless legs syndrome. Ergot derivatives are known to be associated with fibrotic conditions, including a carcinoid-like, fibrotic, valvular heart disease (VHD). Recently, pergolide was identified in association with the development of VHD. This article includes a summary of the literature published on pergolide-associated VHD, a description of the potential mechanisms of drug-induced VHD, and the clinical implications for the management of patients taking pergolide.
培高利特是一种麦角衍生物多巴胺激动剂，用于治疗帕金森病和不宁腿综合征。已知麦角衍生物与纤维化疾病有关，包括类癌样、纤维化瓣膜性心脏病（VHD）。最近，发现培高利特与VHD的发生有关。本文包括关于培高利特相关VHD的文献综述、药物诱导VHD的潜在机制描述以及对服用培高利特患者管理的临床意义。
