Zhu X O, McNaughton N
Department of Psychology, University of Otago, Dunedin, New Zealand.
Neuropharmacology. 1991 Oct;30(10):1095-9. doi: 10.1016/0028-3908(91)90138-2.
Buspirone is effective in treating clinical anxiety but, unlike classical anxiolytics, does not have anti-convulsant, sedative or muscle relaxant side-effects and does not interact with GABA. Buspirone may also differ from classical anxiolytics in requiring a period of 2 weeks or more to achieve its full therapeutic action. It has previously been shown that all anxiolytic drugs, including buspirone, reduce the frequency of reticular-elicited hippocampal rhythmical slow activity (RSA). The present experiments tested whether the time course of the effect of buspirone on rhythmical slow activity differed from that of the anxiolytic benzodiazepine chlordiazepoxide. Rats, implanted with reticular stimulation electrodes and subicular recording electrodes, received three intraperitoneal injections per day of buspirone (2.5 mg/kg), chlordizepoxide (5 mg/kg) or saline for 45 days. Both buspirone and chlordiazepoxide reduced the frequency of rhythmical slow activity on the first day of testing and Ro15-1788 (10 mg/kg) blocked the effects of chlordiazepoxide but not buspirone. There was no increase in the effect of buspirone with time. These results showed that, if the effect of anxiolytic drugs on rhythmical slow activity provides any basis for their clinical action, then some additional factors are required to explain both the delayed action of buspirone and the immediate action of classical anxiolytic drugs.
丁螺环酮在治疗临床焦虑方面有效，但与经典抗焦虑药不同，它没有抗惊厥、镇静或肌肉松弛的副作用，也不与γ-氨基丁酸（GABA）相互作用。丁螺环酮与经典抗焦虑药的另一个不同之处可能在于，它需要2周或更长时间才能达到完全的治疗效果。此前已经表明，所有抗焦虑药物，包括丁螺环酮，都会降低网状结构诱发的海马节律性慢活动（RSA）的频率。本实验测试了丁螺环酮对节律性慢活动的影响的时间进程是否与抗焦虑苯二氮䓬类药物氯氮䓬不同。给植入了网状刺激电极和海马下记录电极的大鼠每天腹腔注射三次丁螺环酮（2.5毫克/千克）、氯氮䓬（5毫克/千克）或生理盐水，持续45天。在测试的第一天，丁螺环酮和氯氮䓬都降低了节律性慢活动的频率，而Ro15 - 1788（10毫克/千克）阻断了氯氮䓬的作用，但没有阻断丁螺环酮的作用。丁螺环酮的效果没有随时间增加。这些结果表明，如果抗焦虑药物对节律性慢活动的影响为其临床作用提供了任何基础，那么就需要一些额外的因素来解释丁螺环酮的延迟作用和经典抗焦虑药物的即时作用。
