对阿根廷不同城市人群的基因结构进行检测。
Testing for genetic structure in different urban Argentinian populations.
作者信息
Toscanini Ulises, Gusmão Leonor, Berardi Gabriela, Amorim António, Carracedo Angel, Salas Antonio, Raimondi Eduardo
机构信息
PRICAI-Fundacion Favaloro, Av. Belgrano 1782, 1er Subsuelo, 1093 Capital Federal, Buenos Aires, Argentina.
出版信息
Forensic Sci Int. 2007 Jan 5;165(1):35-40. doi: 10.1016/j.forsciint.2006.02.042. Epub 2006 Jul 17.
Fifteen autosomal short tandem repeat (STR) markers (D3S1358, HUMTH01, D21S11, D18S51, PENTA E, D5S818, D13S317, D7S820, D16S539, CSF1PO, PENTA D, HUMvWA, D8S1179, HUMTPOX, FGA) were analyzed in 1734 individuals living in urban areas of cities from six different Argentinian provinces (Buenos Aires, Neuquén, Tucumán, La Pampa, San Luis, Santa Cruz) in order to determine if a common urban database could be used in Argentina for forensic purposes. Frequencies estimates, Hardy-Weinberg equilibrium (HWE), and other parameters of forensic interest were computed. Comparisons between the six populations, and with published data from one Native American population from Argentina and other urban populations from Argentina and Europe were also performed. Our results reveal evidences for population structure, both when testing for genetic differentiation and when comparing frequencies distributions between different pairs of populations. Therefore, caution should be taken when using a common pooled database with general forensic purposes in Argentina.
对来自阿根廷六个不同省份（布宜诺斯艾利斯、内乌肯、图库曼、拉潘帕、圣路易斯、圣克鲁斯）城市地区的1734名个体，分析了15个常染色体短串联重复序列（STR）标记（D3S1358、HUMTH01、D21S11、D18S51、PENTA E、D5S818、D13S317、D7S820、D16S539、CSF1PO、PENTA D、HUMvWA、D8S1179、HUMTPOX、FGA），以确定阿根廷是否可以使用一个通用的城市数据库用于法医目的。计算了频率估计值、哈迪-温伯格平衡（HWE）以及其他法医相关参数。还对这六个群体之间进行了比较，并与来自阿根廷一个美洲原住民群体以及阿根廷和欧洲其他城市群体的已发表数据进行了比较。我们的结果揭示了群体结构的证据，无论是在测试遗传分化时，还是在比较不同群体对之间的频率分布时。因此，在阿根廷使用一个通用的汇总数据库用于一般法医目的时应谨慎。
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