Groc Laurent, Choquet Daniel
UMR 5091 CNRS-Université de Bordeaux 2 Physiologie Cellulaire de la Synapse, Institut François Magendie, Rue Camille Saint Saëns, 33077 Bordeaux Cédex, France.
Cell Tissue Res. 2006 Nov;326(2):423-38. doi: 10.1007/s00441-006-0254-9. Epub 2006 Jul 18.
Glutamate receptor trafficking in and out of synapses is one of the core mechanisms for rapid changes in the number of functional receptors during synaptic plasticity. Recent data have shown that the fast gain and loss of receptors from synaptic sites are accounted for by endocytic/exocytic processes and by their lateral diffusion in the plane of the membrane. These events are interdependent and regulated by neuronal activity and interactions with scaffolding proteins. We review here the main cellular steps for AMPA and NMDA receptor synthesis, traffic within intracellular organelles, membrane exocytosis/endocytosis and surface trafficking. We focus on new findings that shed light on the regulation of receptor cycling events and surface trafficking and the way that this might reshape our thinking about the specific regulation of receptor accumulation at synapses.
谷氨酸受体进出突触的运输是突触可塑性期间功能性受体数量快速变化的核心机制之一。最近的数据表明，突触部位受体的快速增减是由内吞/外排过程及其在膜平面内的横向扩散所导致的。这些事件相互依存，并受神经元活动以及与支架蛋白相互作用的调控。我们在此综述了AMPA和NMDA受体合成、细胞内细胞器内运输、膜胞吐/内吞以及表面运输的主要细胞步骤。我们重点关注了一些新发现，这些发现有助于阐明受体循环事件和表面运输的调控，以及这可能如何重塑我们对突触处受体积累特定调控的认识。
