Hansell N K, James M R, Duffy D L, Birley A J, Luciano M, Geffen G M, Wright M J, Montgomery G W, Martin N G
Genetic Epidemiology, Queensland Institute of Medical Research, University of Queensland, Brisbane, Australia.
Genes Brain Behav. 2007 Apr;6(3):260-8. doi: 10.1111/j.1601-183X.2006.00254.x. Epub 2006 Jul 17.
Brain-derived neurotrophic factor (BDNF) may play a role in modulating memory function and there is growing evidence that the BDNF V166M polymorphism may influence episodic memory in humans. However, previous association studies examining this polymorphism and working memory are inconsistent. The current study examined this association in a large sample of adolescent twin-pairs and siblings (785 individuals from 439 families). A range of measures (event-related potential, general performance and reaction time) was obtained from a delayed-response working-memory task and total association was examined using the quantitative transmission disequilibrium tests (QTDT) program. Analyses had approximately 93-97% power (alpha= 0.05) to detect an association accounting for as little as 2% of the variance in the phenotypes examined. Results indicated that the BDNF V166M polymorphism is not associated with variation in working memory in healthy adolescents.
脑源性神经营养因子（BDNF）可能在调节记忆功能中发挥作用，并且越来越多的证据表明BDNF V166M基因多态性可能会影响人类的情景记忆。然而，之前研究这种多态性与工作记忆之间关系的关联研究结果并不一致。本研究在大量青少年双胞胎对和兄弟姐妹样本（来自439个家庭的785人）中检验了这种关联。从延迟反应工作记忆任务中获得了一系列测量指标（事件相关电位、总体表现和反应时间），并使用定量传递不平衡检验（QTDT）程序检验了总体关联。分析具有约93 - 97%的检验效能（α = 0.05），以检测占所检查表型变异低至2%的关联。结果表明，BDNF V166M基因多态性与健康青少年工作记忆的变异无关。
