共价连接到聚（甲基丙烯酸）上的卟啉与脂质体膜的相互作用。
Interactions of porphyrin covalently attached to poly(methacrylic acid) with liposomal membranes.
作者信息
Kepczyński Mariusz, Karewicz Anna, Górnicki Andrzej, Nowakowska Maria
机构信息
Faculty of Chemistry, Jagiellonian University, 30-060 Kraków, Ingardena 3, Poland.
出版信息
J Phys Chem B. 2005 Jan 27;109(3):1289-94. doi: 10.1021/jp046726p.
The interactions between the 5-(4-acryloyloxyphenyl)-10,15,20-tritolylporphyrin covalently attached to poly(methacrylic acid) chain (PMA-Po) and phosphatidylcholine liposomes in aqueous solution at different pH values were studied. The binding constants (K(b)) for the liposome- PMA-Po in solutions in the pH range from 6.5 to 9.2 were determined using fluorescence spectroscopy. The binding was found to be efficient. The acid-base properties of the porphyrin chromophores were also studied. Both pK values associated with imine-N protonation of the porphyrin core were found to be 6.4. The quantum yield (Phi(Delta)) of singlet oxygen production by Po in the lipid-PMA-Po system was found to be high (0.88 +/- 0.05).
研究了共价连接到聚（甲基丙烯酸）链（PMA-Po）上的5-（4-丙烯酰氧基苯基）-10,15,20-三苯基卟啉与磷脂酰胆碱脂质体在不同pH值水溶液中的相互作用。使用荧光光谱法测定了pH范围为6.5至9.2的溶液中脂质体-PMA-Po的结合常数（K(b)）。发现结合是有效的。还研究了卟啉发色团的酸碱性质。发现与卟啉核心亚胺-N质子化相关的两个pK值均为6.4。发现脂质-PMA-Po系统中Po产生单线态氧的量子产率（Phi(Delta)）很高（0.88±0.05）。
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