乙酰胆碱跨水与脂质修饰的1,2-二氯乙烷界面离子转移的电化学研究。

Electrochemical study of ion transfer of acetylcholine across the interface of water and a lipid-modified 1,2-dichloroethane.

作者信息

Gulaboski Rubin, Pereira Carlos M, Cordeiro M Natália D S, Bogeski Ivan, Ferreira Elisabete, Ribeiro David, Chirea Mariana, Silva A Fernando

机构信息

Departamento de Quimica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal.

出版信息

J Phys Chem B. 2005 Jun 30;109(25):12549-59. doi: 10.1021/jp050929b.

DOI:10.1021/jp050929b

PMID:16852552

Abstract

The ion transfer of acetylcholine (AcH(+)) ions across the unmodified and phospholipid-modified water|1,2-dichloroethane (DCE) interface has been studied by means of square-wave and cyclic voltammetry, as well as by electrochemical impedance spectroscopy. After being transferred in the organic phase, the AcH(+) ions undergo chemical reactions with the phospholipids. The overall behavior of the experimental system studied in the presence of phospholipids has been compared with the theoretical results of an ECrev reaction. The kinetic parameters of the chemical interactions between AcH(+) and the phospholipids have been determined from the voltammetric and impedance measurements. Additional characterization of those interactions has been made by using the surface tension measurements.

摘要

已通过方波伏安法、循环伏安法以及电化学阻抗谱研究了乙酰胆碱（AcH(+)）离子在未修饰和磷脂修饰的水|1,2 - 二氯乙烷（DCE）界面上的离子转移。在有机相中转移后，AcH(+)离子与磷脂发生化学反应。已将在磷脂存在下所研究实验系统的整体行为与ECrev反应的理论结果进行了比较。已从伏安法和阻抗测量中确定了AcH(+)与磷脂之间化学相互作用的动力学参数。通过表面张力测量对这些相互作用进行了额外的表征。