摘除眼球对猫视网膜靶区中N-乙酰天门冬氨酰谷氨酸免疫反应性的影响。

Effect of eye removal on N-acetylaspartylglutamate immunoreactivity in retinal targets of the cat.

作者信息

Tieman S B, Moffett J R, Irtenkauf S M

机构信息

Neurobiology Research Center, State University of New York, Albany 12222.

出版信息

Brain Res. 1991 Oct 25;562(2):318-22. doi: 10.1016/0006-8993(91)90638-c.

DOI:10.1016/0006-8993(91)90638-c

PMID:1685346

Abstract

The endogenous brain dipeptide N-acetylaspartylglutamate (NAAG) has previously been demonstrated in the somata of retinal ganglion cells and the neuropil of retinal targets. In this paper we report that the NAAG immunoreactivity of the neuropil in the retinal targets is dependent on an intact optic pathway. Removal of one eye produced a marked decrease in the staining of the neuropil in layer A of the contralateral geniculate nucleus (LGN) and layer A1 of the ipsilateral LGN. There was also decreased staining in the superficial layers of the superior colliculus contralateral to the removal. These results suggest that NAAG is present in the terminals of retinal ganglion cells and is consistent with a role for NAAG in visual synaptic transmission.

摘要

内源性脑二肽N-乙酰天冬氨酰谷氨酸（NAAG）先前已在视网膜神经节细胞的胞体和视网膜靶标的神经毡中得到证实。在本文中，我们报告视网膜靶标中神经毡的NAAG免疫反应性依赖于完整的视路。摘除一只眼睛会导致对侧膝状核（LGN）A层和同侧LGN A1层神经毡染色显著减少。摘除眼睛对侧的上丘表层染色也减少。这些结果表明NAAG存在于视网膜神经节细胞的终末，并且与NAAG在视觉突触传递中的作用相符。