Moriya Fumio, Hashimoto Yoshiaki, Furumiya Junichi
Department of Legal Medicine, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku City, Kochi 783-8505, Japan.
Forensic Sci Int. 2007 May 24;168(2-3):102-5. doi: 10.1016/j.forsciint.2006.06.049. Epub 2006 Jul 18.
Cigarette smoking is associated with a higher risk for suicide. The present study was conducted on the hypothesis that suicide smokers show higher nicotine and cotinine levels in blood and urine than non-suicide smokers. We determined nicotine and cotinine levels in blood and urine of 87 deceased individuals (18 suicides and 69 non-suicides) by gas chromatography. The smoking rate was 77.8% for individuals who committed suicide and 42.0% for those who did not commit suicide. Average nicotine and cotinine levels in blood were significantly higher in the suicide smokers than in the non-suicide smokers (nicotine: 93.2+/-46.6 ng/ml versus 25.8+/-14.4 ng/ml, p<0.0001 and cotinine: 378+/-235 ng/ml versus 201+/-137 ng/ml, p<0.005). Average levels of urinary nicotine and cotinine were also significantly higher in the suicide smokers than in the non-suicide smokers (nicotine: 1980+/-2210 ng/ml versus 394+/-376 ng/ml, p<0.005 and cotinine: 1170+/-1330 ng/ml versus 414+/-290 ng/ml, p<0.05). Twenty-six decedents were intoxicated with alcohol, and they included 7 suicides (7 smokers) and 19 non-suicides (15 smokers). Our data suggest that cigarette smokers who commit suicide smoke more heavily than other cigarette smokers.
吸烟与更高的自杀风险相关。本研究基于这样的假设开展：自杀的吸烟者血液和尿液中的尼古丁和可替宁水平高于非自杀的吸烟者。我们通过气相色谱法测定了87名死者（18名自杀者和69名非自杀者）血液和尿液中的尼古丁和可替宁水平。自杀者的吸烟率为77.8%，非自杀者的吸烟率为42.0%。自杀吸烟者血液中的尼古丁和可替宁平均水平显著高于非自杀吸烟者（尼古丁：93.2±46.6纳克/毫升对25.8±14.4纳克/毫升，p<0.0001；可替宁：378±235纳克/毫升对201±137纳克/毫升，p<0.005）。自杀吸烟者尿液中的尼古丁和可替宁平均水平也显著高于非自杀吸烟者（尼古丁：1980±2210纳克/毫升对394±376纳克/毫升，p<0.005；可替宁：1170±1330纳克/毫升对414±290纳克/毫升，p<0.05）。26名死者酒精中毒，其中包括7名自杀者（7名吸烟者）和19名非自杀者（15名吸烟者）。我们的数据表明，自杀的吸烟者比其他吸烟者吸烟量更大。
