在细胞模型中显示出功效的肉毒杆菌神经毒素A蛋白酶抑制剂的鉴定。
Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model.
作者信息
Boldt Grant E, Eubanks Lisa M, Janda Kim D
机构信息
Department of Chemistry and Immunology, Skaggs Institute for Chemical Biology, Worm Institute for Research Medicine (WIRM), Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Chem Commun (Camb). 2006 Aug 7(29):3063-5. doi: 10.1039/b603099h. Epub 2006 May 3.
DOI:10.1039/b603099h
PMID:16855686
Abstract
Herein we describe a small-molecule, non-peptidic, inhibitor for botulinum neurotoxin A protease, that displays for the first time efficacy in a cell-based assay.
摘要
在此，我们描述了一种用于肉毒杆菌神经毒素A蛋白酶的小分子非肽类抑制剂，其在基于细胞的试验中首次显示出疗效。
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