4-硫代尿苷生物合成过程中酶促过硫化物和二硫化物中间体的直接证据。
Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis.
作者信息
Wright Chapman M, Christman Glenn D, Snellinger Ann M, Johnston Murray V, Mueller Eugene G
机构信息
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
出版信息
Chem Commun (Camb). 2006 Aug 7(29):3104-6. doi: 10.1039/b604040c. Epub 2006 Jun 14.
DOI:10.1039/b604040c
PMID:16855700
Abstract
Two proposed mechanisms for 4-thiouridine generation share key cysteine persulfide and disulfide intermediates, and indirect evidence of their existence has been previously reported; chemical trapping and mass spectrometry have now provided direct and definitive evidence of these key intermediates.
摘要
两种关于4-硫尿苷生成的机制共享关键的半胱氨酸过硫化物和二硫化物中间体，此前已有关于它们存在的间接证据报道；化学捕获和质谱分析现已提供了这些关键中间体的直接确凿证据。
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