Liu Jia-jia, Zhou Dan, Tang Ke-wen
College of Chemistry and Chemical Engineering, Central South University, Changsha, China.
Yao Xue Xue Bao. 2006 Apr;41(4):376-9.
To establish a resolution method for alpha-cyclohexyl mandelic acid enantiomers by enantioselective extraction and to observe the effects of all kinds of tartaric esters, pH, the concentration of D-tartaric esters and beta-cyclodextrin on the enantioselectivity.
Resolution of alpha-cyclohexyl mandelic acid enantiomers by enantioselective extraction with tartaric esters and beta-cyclodextrin has been studied.
The distribution behavior of alpha-cyclohexyl mandelic acid enantiomers in the separation system was studied. The effects of all kinds of tartaric esters, pH, the concentration of D-tartaric esters and beta-cyclodextrin on the enantioselectivity has been examined in the two-phase.
Results showed that the complex formed by D-iso-butyl-D-tartaric ester with R enantiomer is stabler than that with S enantiomer. With the increase of pH, the partition coefficient and separation factor decreased. The concentration of beta-cyclodextrin and D-tartaric ester had visible effect on the enantioselectivity.
通过对映选择性萃取建立α-环己基扁桃酸对映体的拆分方法，并观察各类酒石酸酯、pH值、D-酒石酸酯浓度和β-环糊精对对映选择性的影响。
研究了用酒石酸酯和β-环糊精通过对映选择性萃取拆分α-环己基扁桃酸对映体。
研究了α-环己基扁桃酸对映体在分离体系中的分配行为。考察了各类酒石酸酯、pH值、D-酒石酸酯浓度和β-环糊精在两相中对对映选择性的影响。
结果表明，D-异丁基-D-酒石酸酯与R对映体形成的络合物比与S对映体形成的络合物更稳定。随着pH值的升高，分配系数和分离因子降低。β-环糊精和D-酒石酸酯的浓度对对映选择性有明显影响。
