Yanagisawa Nobuaki, Abe Shinichi, Agematsu Hiroko, Sakiyama Koji, Usami Akinobu, Tamatsu Yuichi, Ide Yoshinobu
Department of Anatomy, Tokyo Dental College, 1-2-2 Masago, Mihama-Ku, Chiba 261-8502, Japan.
Ann Anat. 2006 Jul;188(4):329-36. doi: 10.1016/j.aanat.2006.02.004.
To elucidate the effects of teeth on muscle fibers in the tongue during the developmental process, we examined the expression of muscle contractile proteins and the genes for those proteins in normal mice and microphthalmic (mi/mi) mice with impaired tooth eruption. The mice were observed during the growth period, including weaning, which is when feeding movements undergo major changes. Expression of the myosin heavy chain (MyHC)-2a protein, whose contraction speed is relatively slow, disappeared after weaning in normal mice, while it remained in high concentrations even after weaning in mi/mi mice. The presence of MyHC-2a after weaning in mice with no tooth eruption was attributed to a compensation for lack of proper masticatory function and sucking-like movements, as MyHC-2a is necessary for these movements.
为了阐明在发育过程中牙齿对舌肌纤维的影响，我们检测了正常小鼠和牙齿萌出受损的小眼（mi/mi）小鼠中肌肉收缩蛋白及其相关基因的表达。在包括断奶期在内的生长期间观察这些小鼠，断奶期是进食运动发生重大变化的时期。收缩速度相对较慢的肌球蛋白重链（MyHC）-2a蛋白在正常小鼠断奶后表达消失，而在mi/mi小鼠中，即使断奶后该蛋白仍保持高浓度。在无牙齿萌出的小鼠断奶后仍存在MyHC-2a，这归因于对缺乏适当咀嚼功能和类似吮吸运动的补偿，因为这些运动需要MyHC-2a。
