Kim Ju, Schafer Julie, Ming Guo-li
Johns Hopkins University School of Medicine, Institute for Cell Engineering, Department of Neurology, 733 N. Broadway, BRB 706, Baltimore, MD 21205, USA.
Expert Opin Biol Ther. 2006 Aug;6(8):735-8. doi: 10.1517/14712598.6.8.735.
Neurons in the adult mammalian central nervous system (CNS) do not spontaneously regenerate their axons after injury. Despite significant progress in the field of axonal regeneration, effective therapeutic strategies to promote functional recovery after injury are not available. The development of novel therapeutics will require further insights into the intrinsic and extrinsic mechanisms that restrict regeneration in the adult CNS. It is equally important that the mechanisms mediating the restoration of axonal connectivity must be determined. This review summarises the known molecular mechanisms of neurite outgrowth inhibition after CNS injury and provides new insights into the potential future direction of neuroregeneration research.
成年哺乳动物中枢神经系统（CNS）中的神经元在受伤后不会自发地再生其轴突。尽管轴突再生领域取得了重大进展，但仍没有有效的治疗策略来促进损伤后的功能恢复。新型疗法的开发将需要进一步深入了解限制成年中枢神经系统再生的内在和外在机制。同样重要的是，必须确定介导轴突连接恢复的机制。这篇综述总结了中枢神经系统损伤后神经突生长抑制的已知分子机制，并为神经再生研究未来的潜在方向提供了新的见解。
