Uehara Shinya, Monden Koichi, Nomoto Koji, Seno Yuko, Kariyama Reiko, Kumon Hiromi
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata, Okayama 700-8558, Japan.
Int J Antimicrob Agents. 2006 Aug;28 Suppl 1:S30-4. doi: 10.1016/j.ijantimicag.2006.05.008. Epub 2006 Jul 20.
Changes in the indigenous vaginal microflora with uropathogenic bacteria can predispose women to frequently recurring bacterial cystitis. Lactobacilli used as probiotics have played an important role in preventing the colonization of pathogenic bacteria in the vagina. A prospective clinical pilot study was performed to confirm the safety and effectiveness of Lactobacillus vaginal suppositories against the recurrence of bacterial urinary tract infection (UTI). The patients enrolled in the study were instructed to administer vaginal suppositories containing the strain Lactobacillus crispatus GAI 98322. A significant reduction in the number of recurrences was noted, without any adverse complication (P=0.0007). The administration of vaginal suppositories containing L. crispatus GAI 98332 seemed to be a safe and promising treatment for the prevention of recurrent UTI.
本土阴道微生物群与尿路致病菌的变化会使女性易患复发性细菌性膀胱炎。用作益生菌的乳酸杆菌在预防病原菌在阴道定植方面发挥了重要作用。进行了一项前瞻性临床试点研究，以确认阴道用乳酸杆菌栓剂预防细菌性尿路感染（UTI）复发的安全性和有效性。参与该研究的患者被指示使用含有卷曲乳酸杆菌GAI 98322菌株的阴道栓剂。复发病例数显著减少，且无任何不良并发症（P = 0.0007）。使用含有卷曲乳酸杆菌GAI 98332的阴道栓剂似乎是预防复发性UTI的一种安全且有前景的治疗方法。
