Kapreli Eleni, Athanasopoulos Spyros, Papathanasiou Matilda, Van Hecke Paul, Strimpakos Nikolaos, Gouliamos Athanasios, Peeters Ronald, Sunaert Stefan
Faculty of Physical Education and Sports Science, Laboratory of Sports Physiotherapy, National and Kapodistrian University of Athens, Greece, and Department of Radiology, University Hospitals of K. U. Leuven, Belgium.
Neuroimage. 2006 Oct 1;32(4):1709-21. doi: 10.1016/j.neuroimage.2006.05.043. Epub 2006 Jul 21.
Studies of unilateral finger movement in right-handed subjects have shown asymmetrical patterns of activation in primary motor cortex and subcortical regions. In order to investigate the existence of an analogous pattern during lower limb joints movements, functional magnetic resonance imaging (fMRI) was used. Eighteen healthy, right leg dominant volunteers participated in a motor block design study, performing unilateral right and left repetitive knee, ankle and toes flexion/extension movements. Aiming to relate lower limb joints activation to the well-described patterns of finger movement, serial finger-to-thumb opposition was also assessed. All movements were auditory paced at 72 beats/min (1.2 Hz). Brain activation during movement of the nondominant joints was more bilateral than during the same movement performed with the dominant joints. Finger movement had a stronger lateralized pattern of activation in comparison with lower limb joints, implying a different functional specialization. Differences were also evident between the joints of the lower limb. Ankle and toes movements elicited the same extend of MR signal change in the majority of the examined brain regions, whereas knee joint movement was associated with a different pattern. Finally, lateralization index in primary sensorimotor cortex and basal ganglia was significantly affected by the main effect of dominance, whereas the lateralization index in cerebellum was significantly affected by the joint main effect, demonstrating a lateralization index increase from proximal to distal joints.
对右利手受试者单侧手指运动的研究表明，初级运动皮层和皮层下区域存在不对称的激活模式。为了研究下肢关节运动过程中是否存在类似模式，采用了功能磁共振成像（fMRI）。18名健康的、右腿优势的志愿者参与了一项运动组块设计研究，进行单侧右、左重复性膝关节、踝关节和脚趾屈伸运动。为了将下肢关节激活与已充分描述的手指运动模式联系起来，还评估了连续的手指对拇指对掌运动。所有运动均由听觉节拍器以72次/分钟（1.2赫兹）的速度进行。与优势关节进行相同运动时相比，非优势关节运动期间的脑激活在双侧更为明显。与下肢关节相比，手指运动具有更强的偏侧化激活模式，这意味着功能特化有所不同。下肢关节之间的差异也很明显。踝关节和脚趾运动在大多数检查的脑区引起相同程度的磁共振信号变化，而膝关节运动则与不同的模式相关。最后，初级感觉运动皮层和基底神经节的偏侧化指数受优势主效应的显著影响，而小脑的偏侧化指数受关节主效应的显著影响，表明从近端关节到远端关节偏侧化指数增加。
