Jäncke L, Specht K, Mirzazade S, Peters M
Department of General Psychology, Otto-von-Guericke-University, Magdeburg, D-39112, Germany.
Neuroimage. 1999 May;9(5):497-507. doi: 10.1006/nimg.1998.0426.
We studied the effects of different speeds of unimanual and bimanual movements on functional magnetic resonance signal changes in the cerebellum. Six healthy consistently right-handed subjects were scanned at rest and while executing a sequential finger-to-thumb-opposition task either unimanually (left or right hand) or bimanually. Movement frequency was paced by an auditory signal at rates of either 1 or 3 Hz. Significant frequency-dependent blood oxygen level-dependent signal increases were demonstrated ipsilaterally and contralaterally in the intermediate and lateral portions of the anterior cerebellum for bimanual movements and for unimanual movements with the subdominant hand. There was only a weak frequency-dependent effect for unimanual movements performed with the dominant hand. In addition, signals were stronger on the right intermediate zone of the anterior cerebellum for movements involving the right (dominant) hand while there was stronger activity on the left cerebellar hemisphere for movements involving the left (subdominant) hand. Taken together, these results suggest that rate and movement task effects on cerebellar activation are differentially sensitive to subdominant and dominant hand movements.
我们研究了单手和双手运动的不同速度对小脑功能磁共振信号变化的影响。对6名一贯惯用右手的健康受试者在静息状态下以及在执行顺序性手指对拇指对掌任务时进行扫描，任务执行方式为单手（左手或右手）或双手。运动频率由听觉信号以1Hz或3Hz的速率进行调节。对于双手运动以及用非优势手进行的单手运动，在前小脑的中间和外侧部分同侧和对侧均显示出显著的频率依赖性血氧水平依赖性信号增加。对于用优势手进行的单手运动，仅存在微弱的频率依赖性效应。此外，涉及右手（优势手）的运动在前小脑右侧中间区域的信号更强，而涉及左手（非优势手）的运动在左小脑半球的活动更强。综上所述，这些结果表明，速率和运动任务对小脑激活的影响对非优势手和优势手运动的敏感性不同。
