Le Maître Erwan, Daubeuf François, Duterte-Boucher Dominique, Costentin Jean, Leroux-Nicollet Isabelle
Unité de Neuropsychopharmacologie de la Dépression, Faculté de Médecine-Pharmacie, Rouen Cedex 1, France.
Brain Res. 2006 Sep 19;1110(1):144-9. doi: 10.1016/j.brainres.2006.06.074. Epub 2006 Jul 24.
We studied the involvement of endogenous ORL1 (NOP) receptors in the anxiety state. In mice selected as "anxious" and "non-anxious", ORL1 (NOP) receptor has been analysed by means of two autoradiographic approaches: [3H]nociceptin binding and nociceptin-stimulated [35S]GTPgammaS binding. We show that differences in anxiety state are associated with differences in G protein coupling efficiency of ORL1 (NOP) receptor in the nucleus accumbens, without any change in the density of the receptors.
我们研究了内源性孤啡肽受体1（NOP）在焦虑状态中的作用。在被选为“焦虑”和“非焦虑”的小鼠中，通过两种放射自显影方法分析了孤啡肽受体1（NOP）：[3H]孤啡肽结合和孤啡肽刺激的[35S]GTPγS结合。我们发现，焦虑状态的差异与伏隔核中孤啡肽受体1（NOP）的G蛋白偶联效率差异有关，而受体密度没有任何变化。
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