Lahrts H G, Scheimmel K
Schweiz Med Wochenschr. 1975 Apr 26;105(17):535-8.
Exophthalmos has been induced in carp by injecting thyrotropin releasing hormone (TRH) (PYRO-glutamyl-histidyl-prolinamide) into the coelom. This effect was dose-dependent (dose range 5-750 mug). It was significantly potentiated by prior administration of beta-1 minus 24 coricotropin (Synacthen, Ciba) and inhibited by prednisclone. No significant increase was obtained with 2-phenylalanine-8-lysire-vasopressin (Octapressin, Sandoz). The results show that in the fish model, TRH exerts an exophthalmogenic effect by stimulating endogenous TSH, whereas in man this is not the case. They afford further evidence that the carp model does not reproduce the conditions which occur in ophthalmic Graves' disease.
通过向鲤鱼体腔注射促甲状腺激素释放激素（TRH）（焦谷氨酰 - 组氨酰 - 脯氨酰胺）可诱发突眼。这种效应呈剂量依赖性（剂量范围为5 - 750微克）。预先给予β - 1至24促肾上腺皮质激素（新促皮质素，汽巴公司）可显著增强该效应，而泼尼松龙可抑制此效应。2 - 苯丙氨酸 - 8 - 赖氨酸 - 血管加压素（奥曲肽，山德士公司）未引起显著增加。结果表明，在鱼类模型中，TRH通过刺激内源性促甲状腺激素发挥致突眼作用，而在人类中并非如此。它们进一步证明鲤鱼模型不能重现甲状腺性突眼性格雷夫斯病所出现的情况。
