Horwitz K B, McGuire W L
Science. 1975 Aug 29;189(4204):726-7. doi: 10.1126/science.168640.
We hypothesize that the presence of progesterone receptors in human breast tumors may be a sensitive marker for predicting response to endocrine therapy. Progesterone receptors were found in 56 percent of tumors with estrogen receptors, but were absent in tumors without estrogen receptors. Preliminary clinical correlations show that only those breast tumors with progesterone receptors regressed after endocrine therapy.
我们推测，人类乳腺肿瘤中孕激素受体的存在可能是预测内分泌治疗反应的一个敏感标志物。在56%有雌激素受体的肿瘤中发现了孕激素受体，但在没有雌激素受体的肿瘤中则不存在。初步的临床相关性研究表明，只有那些有孕激素受体的乳腺肿瘤在内分泌治疗后出现消退。
