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[Antisecretory drugs, hypergastrinemia and hyperplasia of enterochromaffin-like cells (ECL)].

作者信息

Andriulli A, Mangia A, Lawson F

机构信息

Divisione di Gastroenterologia, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia.

出版信息

Minerva Gastroenterol Dietol. 1991 Jul-Sep;37(3):135-40.

PMID:1686409
Abstract

A review of the literature was carried out in order to identify those mechanisms responsible for hyperplasia of Enterochromaffin-like cells (ECL) undergoing treatment with antisecretory drugs. All gastric acid secretion-inhibiting drugs cause a physiological increase in gastrinemia due to their inhibitory function. ECL hyperplasia is the consequence of the duration of hypergastrinemia. To date no factors responsible for the possible transformation of hyperplasia into carcinoma have yet been identified.

摘要

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Time-dependent changes in enterochromaffin-like cell kinetics in stomach of hypergastrinemic rats.
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