Buyukkocak Unase, Caglayan Osman, Daphan Cagatay, Aydinuraz Kuzey, Saygun Oral, Agalar Fatih
Department of Anaesthesiology and Reanimation, School of Medicine, Kirikkale Univeristy, 71100 Kirikkale, Turkey.
Mediators Inflamm. 2006;2006(1):97257. doi: 10.1155/MI/2006/97257.
Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to general and spinal anaesthesia groups (n = 7). Blood samples were drawn before induction and 24 hours after surgery. Perioperative levels of IL-6, TNF-alpha, CRP, cortisol, and leptin were comparable among the groups. Twenty four hours after surgery, TNF-alpha and cortisol did not change; IL-6 and CRP increased significantly in all patients. Significant increase in leptin levels was found in patients undergoing spinal anaesthesia. Except for the increase in leptin levels, there was no significant difference related to the effects of general and spinal anaesthesia.
手术会促使神经内分泌激素(皮质醇)、细胞因子(白细胞介素-6:IL-6、肿瘤坏死因子-α:TNF-α)、急性期蛋白(C反应蛋白:CRP、瘦素)的释放。我们研究了全身麻醉和脊髓麻醉对痔切除术应激反应的影响。患者被分为全身麻醉组和脊髓麻醉组(每组n = 7)。在诱导麻醉前和手术后24小时采集血样。两组患者围手术期的IL-6、TNF-α、CRP、皮质醇和瘦素水平相当。术后24小时,TNF-α和皮质醇没有变化;所有患者的IL-6和CRP显著升高。接受脊髓麻醉的患者瘦素水平显著升高。除了瘦素水平升高外,全身麻醉和脊髓麻醉的效果没有显著差异。