Buyukkocak Unase, Caglayan Fatma, Caglayan Osman, Basar Murat, Cakmak Murat, Batislam Ertan, Ulusoy Sevgi
Department of Anaesthesiology and Ranimation, School of Medicine, Kirikkale University, Turkey.
Mediators Inflamm. 2005 Oct 24;2005(5):312-5. doi: 10.1155/MI.2005.312.
Concentrations of acute phase proteins (CRP: C-reactive protein, albumin) change during surgery. We investigated the acute phase response to circumcision and the effects of anaesthesia on this response. The children were divided into four groups; group 1 (intratracheal general anaesthesia, n=40), group 2 (general anaesthesia with mask, n=20), group 3 (ketamine, n=20), group 4 (local anaesthesia, n=35). Blood samples were obtained, 24 hours before circumcision, after premedication, and 24 hours after circumcision. CRP and albumin before circumcision were comparable for all groups. There was no increase in CRP, and albumin remained steady throughout the study. No difference was observed among the groups, and related to anaesthesia. No responsiveness may be explained with the size of injured tissue or anatomical and histological type of preputium.
急性期蛋白（CRP：C反应蛋白、白蛋白）的浓度在手术过程中会发生变化。我们研究了包皮环切术的急性期反应以及麻醉对此反应的影响。将儿童分为四组；第1组（气管内全身麻醉，n = 40），第2组（面罩全身麻醉，n = 20），第3组（氯胺酮，n = 20），第4组（局部麻醉，n = 35）。在包皮环切术前24小时、术前用药后以及包皮环切术后24小时采集血样。所有组术前的CRP和白蛋白水平具有可比性。CRP没有升高，且白蛋白在整个研究过程中保持稳定。各组之间未观察到差异，且与麻醉无关。无反应性可能与受伤组织的大小或包皮的解剖学和组织学类型有关。
