Atula Timo, Hedström Johan, Ristimäki Ari, Finne Patrik, Leivo Ilmo, Markkanen-Leppänen Mari, Haglund Caj
Department of Otorhino-laryngology, Head and Neck Surgery, FIN-00029 HUS, Helsinki, Finland.
Oncol Rep. 2006 Sep;16(3):485-90.
Cyclooxygenase-2 (COX-2) expression is up-regulated in transformed cells and in malignant tissues, including tumours of the head and neck, and it has prognostic significance in many types of cancer. COX-2 expression is suppressed by the wild-type but not by the mutant tumour suppressor gene TP53. The purpose of this study was to investigate the association between the expression of COX-2 and the clinical outcome in patients with oral and pharyngeal squamous cell carcinoma (SCC), and to examine its relationship to p53. Immunohistochemistry showed an elevated COX-2 expression in 88% (n = 57; strong 38, weak 19) of the 65 tumour samples. The staining intensity was not associated with patient or tumour characteristics, nor with the immuhistochemical expression of p53. Kaplan-Meier analysis showed no significant correlation between COX-2 expression and recurrence-free or overall survival, but a strong p53 expression was associated with a poor recurrence-free (p = 0.001, log-rank) and overall survival (p = 0.003). We conclude that, unlike strong p53 expression, COX-2 expression does not have prognostic significance in advanced oral and pharyngeal SCCs.
环氧化酶-2（COX-2）在转化细胞和恶性组织（包括头颈部肿瘤）中表达上调，且在多种癌症中具有预后意义。野生型肿瘤抑制基因TP53可抑制COX-2表达，而突变型TP53则不能。本研究旨在探讨口腔和咽鳞状细胞癌（SCC）患者中COX-2表达与临床结局之间的关联，并研究其与p53的关系。免疫组织化学显示，65例肿瘤样本中有88%（n = 57；强阳性38例，弱阳性19例）的COX-2表达升高。染色强度与患者或肿瘤特征无关，也与p53的免疫组织化学表达无关。Kaplan-Meier分析显示，COX-2表达与无复发生存率或总生存率之间无显著相关性，但p53强表达与无复发生存率低（p = 0.001，对数秩检验）和总生存率低（p = 0.003）相关。我们得出结论，与p53强表达不同，COX-2表达在晚期口腔和咽SCC中不具有预后意义。
