• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用依那西普治疗的类风湿关节炎患者发生内脏利什曼病感染。

Visceral leishmaniasis infection in a patient with rheumatoid arthritis treated with etanercept.

作者信息

Bagalas V, Kioumis I, Argyropoulou P, Patakas D

机构信息

Department of Pulmonary Disease, Aristotle University of Thessaloniki Medical School-G. Papanikolaou Hospital, Exohi, Thessaloniki, 57010, Greece.

出版信息

Clin Rheumatol. 2007 Aug;26(8):1344-5. doi: 10.1007/s10067-006-0356-5. Epub 2006 Jul 25.

DOI:10.1007/s10067-006-0356-5
PMID:16865310
Abstract

Visceral leishmaniasis (VL) is a severe disease that can develop in immunocompromised patients. Antitumor necrosis factor-alpha (TNF-alpha) treatment of rheumatoid arthritis can result in clinical benefits, but with an increased risk of opportunistic infections. Leishmania infection in patients treated with TNF-alpha antagonists is extremely rare; for this reason, we report a patient with VL after etanercept treatment who had an unfavorable outcome.

摘要

内脏利什曼病（VL）是一种可在免疫功能低下患者中发生的严重疾病。类风湿关节炎的抗肿瘤坏死因子-α（TNF-α）治疗可带来临床益处，但机会性感染风险增加。接受TNF-α拮抗剂治疗的患者感染利什曼原虫极为罕见；因此，我们报告一例接受依那西普治疗后发生VL且预后不良的患者。

相似文献

1
Visceral leishmaniasis infection in a patient with rheumatoid arthritis treated with etanercept.用依那西普治疗的类风湿关节炎患者发生内脏利什曼病感染。
Clin Rheumatol. 2007 Aug;26(8):1344-5. doi: 10.1007/s10067-006-0356-5. Epub 2006 Jul 25.
2
Subacute thyroiditis presenting as fever of unknown origin in a patient with rheumatoid arthritis under etanercept treatment.
J Clin Rheumatol. 2010 Mar;16(2):88-9. doi: 10.1097/RHU.0b013e3181d0bd30.
3
Visceral leishmaniasis infection in a rheumatoid arthritis patient treated with infliximab.一名接受英夫利昔单抗治疗的类风湿关节炎患者发生内脏利什曼病感染。
Clin Exp Rheumatol. 2005 Nov-Dec;23(6):891-2.
4
Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: results from the British Society for Rheumatology Biologics Register.接受抗肿瘤坏死因子治疗的类风湿关节炎患者的严重感染率，包括特定部位感染和细菌细胞内感染：来自英国风湿病学会生物制剂登记处的结果。
Arthritis Rheum. 2006 Aug;54(8):2368-76. doi: 10.1002/art.21978.
5
Clinical image: salmonella mycotic aneurysm in a patient receiving etanercept for rheumatoid arthritis.
Arthritis Rheum. 2012 Mar;64(3):942. doi: 10.1002/art.33481.
6
Clinical infection with Strongyloides sterocoralis following etanercept use for rheumatoid arthritis.
Arthritis Rheum. 2005 Apr;52(4):1336-7. doi: 10.1002/art.20882.
7
Surgery in rheumatoid arthritis patients under anti-TNF-alpha therapy: what is the risk?
Clin Rheumatol. 2007 Aug;26(8):1396-7. doi: 10.1007/s10067-007-0585-2. Epub 2007 Feb 21.
8
Sensory-motor axonal multineuropathy during etanercept therapy for rheumatoid arthritis.
Clin Exp Rheumatol. 2009 Mar-Apr;27(2):381.
9
Lethal acute respiratory distress syndrome during anti-TNF-alpha therapy for rheumatoid arthritis.类风湿关节炎抗TNF-α治疗期间发生的致死性急性呼吸窘迫综合征
Clin Rheumatol. 2006 May;25(3):430-2. doi: 10.1007/s10067-005-0008-1. Epub 2005 Oct 1.
10
Septic arthritis of the right ankle caused by Staphylococcus aureus infection in a rheumatoid arthritis patient treated with etanercept.
Mod Rheumatol. 2007;17(4):338-40. doi: 10.1007/s10165-007-0581-z. Epub 2007 Aug 20.

引用本文的文献

1
Case Report: Disseminated leishmaniasis and rheumatoid arthritis: navigating a clinical conundrum.病例报告：播散性利什曼病与类风湿关节炎：应对临床难题。
Front Immunol. 2025 Jun 5;16:1599381. doi: 10.3389/fimmu.2025.1599381. eCollection 2025.
2
Leishmaniasis and tumor necrosis factor alpha antagonists in the Mediterranean basin. A switch in clinical expression.地中海盆地的利什曼病和肿瘤坏死因子-α拮抗剂。临床表型的转变。
PLoS Negl Trop Dis. 2019 Aug 30;13(8):e0007708. doi: 10.1371/journal.pntd.0007708. eCollection 2019 Aug.
3
Tumor necrosis factor alpha neutralization has no direct effect on parasite burden, but causes impaired IFN-γ production by spleen cells from human visceral leishmaniasis patients.

本文引用的文献

1
Visceral leishmaniasis infection in a rheumatoid arthritis patient treated with infliximab.一名接受英夫利昔单抗治疗的类风湿关节炎患者发生内脏利什曼病感染。
Clin Exp Rheumatol. 2005 Nov-Dec;23(6):891-2.
2
Current management: Management of rheumatic diseases in the era of biological anti-rheumatic drugs.当前管理：生物抗风湿药物时代的风湿性疾病管理。
Acta Orthop. 2005 Oct;76(5):614-9. doi: 10.1080/17453670510041673.
3
Granulomatous infections due to tumor necrosis factor blockade: correction.肿瘤坏死因子阻断所致肉芽肿性感染：更正。
肿瘤坏死因子α中和对寄生虫负荷没有直接影响，但会导致人类内脏利什曼病患者脾脏细胞的γ干扰素产生受损。
Cytokine. 2016 Sep;85:184-90. doi: 10.1016/j.cyto.2016.06.013. Epub 2016 Jun 30.
4
New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas.城市周边地区内脏利什曼病流行病学与治疗的新挑战
Drug Dev Res. 2011 Sep;72(6):451-462. doi: 10.1002/ddr.20452.
5
Visceral leishmaniasis in immunosuppressed Caucasian patient.免疫抑制的白种人患者的内脏利什曼病
BMJ Case Rep. 2012 May 8;2012:bcr1120115199. doi: 10.1136/bcr.11.2011.5199.
6
Leishmaniasis, autoimmune rheumatic disease, and anti-tumor necrosis factor therapy, Europe.欧洲的利什曼病、自身免疫性风湿性疾病与抗肿瘤坏死因子治疗
Emerg Infect Dis. 2009 Jun;15(6):956-9. doi: 10.3201/eid1506.090101.
7
Long-term use of an antiinflammatory, curcumin, suppressed type 1 immunity and exacerbated visceral leishmaniasis in a chronic experimental model.在慢性实验模型中，长期使用抗炎药姜黄素会抑制1型免疫并加重内脏利什曼病。
Lab Invest. 2008 Dec;88(12):1329-39. doi: 10.1038/labinvest.2008.90. Epub 2008 Sep 15.
8
Visceral leishmaniasis in a patient with psoriatic arthritis treated with infliximab: reactivation of a latent infection?一名接受英夫利昔单抗治疗的银屑病关节炎患者发生内脏利什曼病：潜伏感染的再激活？
Clin Rheumatol. 2008 Apr;27(4):541-2. doi: 10.1007/s10067-007-0775-y. Epub 2007 Oct 26.
Clin Infect Dis. 2004 Oct 15;39(8):1254-5. doi: 10.1086/424455.
4
[Rare opportunistic disease in a patient treated with immunosuppressive therapy for rheumatoid arthritis].[类风湿关节炎免疫抑制治疗患者中的罕见机会性疾病]
An Med Interna. 2003 May;20(5):276-7.
5
Angiogenesis in rheumatoid arthritis: implications for future therapeutic strategies.类风湿关节炎中的血管生成：对未来治疗策略的影响
Springer Semin Immunopathol. 1998;20(1-2):73-94. doi: 10.1007/BF00832000.
6
Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years.人类利什曼病：过去十年的临床、诊断及化疗进展
Clin Infect Dis. 1997 Apr;24(4):684-703. doi: 10.1093/clind/24.4.684.
7
Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis.类风湿关节炎患者接受抗肿瘤坏死因子α单克隆抗体治疗后细胞密度及黏附分子表达降低。
Arthritis Rheum. 1996 Jul;39(7):1077-81. doi: 10.1002/art.1780390702.
8
Cytokines in the treatment of leishmaniasis: from studies of immunopathology to patient therapy.细胞因子在利什曼病治疗中的应用：从免疫病理学研究到患者治疗
Biotherapy. 1994;7(3-4):223-35. doi: 10.1007/BF01878488.
9
Visceral leishmaniasis and HIV-1 co-infection in southern France.法国南部的内脏利什曼病与HIV-1合并感染
Trans R Soc Trop Med Hyg. 1995 Mar-Apr;89(2):159-62. doi: 10.1016/0035-9203(95)90476-x.
10
Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.活化的巨噬细胞通过一种依赖于L-精氨酸的杀伤机制来破坏细胞内的利什曼原虫（Leishmania major）无鞭毛体。
J Immunol. 1990 Jan 1;144(1):278-83.