Rusciani L, Paradisi A, Alfano C, Chiummariello S, Rusciani A
Istituto di Dermatologia, Università Cattolica del Sacro Cuore, Rome, Italy.
J Drugs Dermatol. 2006 Jul-Aug;5(7):591-5.
Despite their benign nature, keloids may constitute a severe aesthetic and, in some cases, functional problem with important repercussions on patients' quality of life. There is no consensus on keloid treatment and no wholly satisfactory therapy has yet emerged.
To assess the efficacy of cryotherapy in the treatment of keloids.
135 patients with 166 keloids received cryosurgical treatment between 1990 and 2004. Freeze times and number of sessions varied. Scar volume was measured before and after treatment. Median follow-up was 48.6 months (range 12.4-72.6 months).
Of the 166 lesions treated, 79.5% responded very well with a volume reduction of the initial mass of greater than 80% after a median of 3 treatments (range: 1-9). A good result was obtained in 14.5% of lesions, while results were unsatisfactory in 6% of cases. The main adverse effects reported were atrophic depressed scars and residual hypopigmentation (75% of cases). No recurrences arose during the follow-up period (12-72 months).
To date, cryotherapy appears to be the most effective, safe, economic, and easy-to-perform monotherapy to treat keloid lesions and hypertrophic scars.
尽管瘢痕疙瘩本质上是良性的，但它们可能会造成严重的美观问题，在某些情况下还会导致功能问题，对患者的生活质量产生重大影响。目前对于瘢痕疙瘩的治疗尚无共识，也尚未出现完全令人满意的疗法。
评估冷冻疗法治疗瘢痕疙瘩的疗效。
1990年至2004年间，135例患有166个瘢痕疙瘩的患者接受了冷冻手术治疗。冷冻时间和疗程次数各不相同。在治疗前后测量瘢痕体积。中位随访时间为48.6个月（范围12.4 - 72.6个月）。
在接受治疗的166个病灶中，79.5%反应良好，经过中位3次治疗（范围：1 - 9次）后，初始肿物体积减少超过80%。14.5%的病灶取得了良好效果，而6%的病例效果不理想。报告的主要不良反应是萎缩性凹陷瘢痕和残留色素减退（75%的病例）。随访期间（12 - 72个月）未出现复发。
迄今为止，冷冻疗法似乎是治疗瘢痕疙瘩和增生性瘢痕最有效、安全、经济且易于实施的单一疗法。
