Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon 24253, Korea.
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Int J Mol Sci. 2018 Mar 2;19(3):711. doi: 10.3390/ijms19030711.
Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus, these significantly affect patients' quality of life. There have been many studies on hypertrophic scars and keloids; but the mechanisms underlying scar formation have not yet been well established, and prophylactic and treatment strategies remain unsatisfactory. In this review, the authors introduce and summarize classical concepts surrounding wound healing and review recent understandings of the biology, prevention and treatment strategies for hypertrophic scars and keloids.
增生性瘢痕和瘢痕疙瘩是纤维增生性疾病，可能由创伤、烧伤、手术等引起的任何深度皮肤损伤后发生。增生性瘢痕和瘢痕疙瘩在美容方面存在问题，并且与挛缩等功能问题以及瘙痒等主观症状相结合，这些都会严重影响患者的生活质量。已经有许多关于增生性瘢痕和瘢痕疙瘩的研究；但是瘢痕形成的机制尚未得到很好的确立，预防和治疗策略仍然不尽人意。在这篇综述中，作者介绍并总结了有关伤口愈合的经典概念，并回顾了关于增生性瘢痕和瘢痕疙瘩的生物学、预防和治疗策略的最新认识。
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