Paul Małgorzata, Stefaniak Jerzy, Rychlicki Witold, Kacprzak Elzbieta, Mazur-Roszak Małgorzata, Komarnicki Mieczysław
Katedra i Klinika Chorób Tropikalnych i Pasozytniczych, Akademia Medyczna, Poznań.
Wiad Parazytol. 2004;50(3):439-45.
The incidence of non-specific reactions with E. multilocularis antigen in patients with liver malignancies, and the risk of a supradiagnosis of alveolar echinococcosis (AE) in space-occupying lesions in the liver due to neoplastic proliferative diseases were studied. Analysis of specific IgG serum antibody against Em2plus antigenic complex was performed in 11 AE patients in comparison to 76 individuals with malignant neoplasms of abdominal or extra-hepatic location, including some patients with primary hepatocellular cancer or distant metastases to liver, and 42 patients with benign hepatic lesions. Only one false borderline result was reported in a case with colorectal cancer, and dissemination to liver. Low risk of false positive results with E. multilocularis-specific Em2plus antigen in patients with liver malignancies makes the test valuable for practical reasons in a differential diagnosis of irregular tumor masses visualized by imaging techniques.
研究了肝恶性肿瘤患者对多房棘球绦虫抗原的非特异性反应发生率，以及肿瘤增殖性疾病导致肝脏占位性病变超诊断为肺泡型棘球蚴病（AE）的风险。对11例AE患者、76例腹部或肝外恶性肿瘤患者（包括一些原发性肝细胞癌或肝转移患者）以及42例良性肝病变患者进行了针对Em2plus抗原复合物的特异性IgG血清抗体分析。仅在1例伴有肝转移的结肠癌患者中报告了1例假临界结果。肝恶性肿瘤患者使用多房棘球绦虫特异性Em2plus抗原出现假阳性结果的风险较低，基于实际原因，该检测对于通过成像技术可视化的不规则肿瘤块的鉴别诊断具有重要价值。
