进展性轻度认知障碍中阿尔茨海默病改变的临床前证据：一项定性和定量单光子发射计算机断层扫描研究
Preclinical evidence of Alzheimer changes in progressive mild cognitive impairment: a qualitative and quantitative SPECT study.
作者信息
Ishiwata A, Sakayori O, Minoshima S, Mizumura S, Kitamura S, Katayama Y
机构信息
Department of Neurology, Nippon Medical School, Tokyo, Japan.
出版信息
Acta Neurol Scand. 2006 Aug;114(2):91-6. doi: 10.1111/j.1600-0404.2006.00661.x.
OBJECTIVES
Baseline brain single-photon emission computed tomography (SPECT) can predict mild cognitive impairment (MCI) patients at risk for progressive MCI (PMCI).
METHODS
Twenty-eight subjects [12 MCI, 6 with probable Alzheimer's Disease (AD), and 10 normal subjects] underwent baseline brain SPECT and were clinically followed for a mean period of 36 months.
RESULTS
Of 12 MCI patients, 6 progressed to PMCI and 6 remained stable. Baseline SPECT identified asymmetric perfusion reduction in the parahippocampus (-5%), lateral parietal (-8%), and posterior cingulate (-11%) cortices--reductions consistent with that of mild AD--in five of the six PMCI patients. Significant perfusion reduction was observed particularly in the frontal cortices of probable AD when compared with PMCI (P < 0.05).
CONCLUSION
Baseline SPECT can identify brain perfusion abnormalities among patients with MCI for progression to PMCI. This imaging modality may aid in MCI treatment stratification.
目的
基线脑单光子发射计算机断层扫描（SPECT）能够预测有进展为轻度认知障碍（PMCI）风险的轻度认知障碍（MCI）患者。
方法
28名受试者[12名MCI患者、6名可能患有阿尔茨海默病（AD）的患者和10名正常受试者]接受了基线脑SPECT检查，并进行了平均36个月的临床随访。
结果
12名MCI患者中，6名进展为PMCI，6名病情保持稳定。基线SPECT检查发现，6名PMCI患者中有5名患者的海马旁回（-5%）、顶叶外侧（-8%）和扣带回后部（-11%）皮质存在不对称灌注减少，这与轻度AD患者的情况一致。与PMCI患者相比，在可能患有AD的患者的额叶皮质中观察到显著的灌注减少（P<0.05）。
结论
基线SPECT能够识别MCI患者中进展为PMCI的脑灌注异常情况。这种成像方式可能有助于MCI治疗分层。
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