DEFB1基因多态性与巴西儿童感染HIV-1的风险增加

DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children.

作者信息

Milanese Michele, Segat Ludovica, Pontillo Alessandra, Arraes Luiz Claudio, de Lima Filho José Luiz, Crovella Sergio

机构信息

Department of Developmental and Reproductive Sciences, University of Trieste, Trieste, Italy.

出版信息

AIDS. 2006 Aug 1;20(12):1673-5. doi: 10.1097/01.aids.0000238417.05819.40.

DOI:10.1097/01.aids.0000238417.05819.40

PMID:16868452

Abstract

In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of northeastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5' UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.

摘要

在我们的研究中，我们分析了巴西东北部三组儿童中DEFB1基因5'非翻译区（UTR）的三个单核苷酸多态性（SNP），即-52（G/A）、-44（C/G）和-20（G/A），以评估它们在HIV-1感染中的作用。我们的结果使我们能够假设，位于DEFB1基因5'UTR的SNP可作为HIV-1感染风险的标志物。