人类β-防御素1基因中的单核苷酸多态性与意大利儿童的HIV-1感染有关。
A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children.
作者信息
Braida Laura, Boniotto Michele, Pontillo Alessandra, Tovo Pier Angelo, Amoroso Antonio, Crovella Sergio
机构信息
Dipartimento di Scienze delle Riproduzione e dello Sviluppo, University of Trieste, Italy.
出版信息
AIDS. 2004 Jul 23;18(11):1598-600. doi: 10.1097/01.aids.0000131363.82951.fb.
In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.
在本研究中，我们发现DEFB1基因5'-非翻译区的单核苷酸多态性与意大利儿科人群（97名围产期感染HIV-1的儿童）感染HIV-1的风险之间存在显著相关性，该单核苷酸多态性可能调控人类β-防御素1（hBD-1）的基因表达，这表明先天免疫在HIV-1感染中具有重要作用。
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