Sutor Bruce, Hansen Mark R, Black John L
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 5905, USA.
Downs Syndr Res Pract. 2006 Jul;10(1):1-3. doi: 10.3104/case-studies.299.
In this case series we report four cases of patients with Down syndrome with symptoms consistent with obsessive compulsive disorder. Each patient experienced substantial reduction in compulsive behaviors with pharmacotherapy of an SSRI alone or with the addition of risperidone to SSRI therapy. None of the patients experienced significant side effects. This small case series supports the use of these medications in the treatment of co-morbid obsessive compulsive disorder in patients with Down syndrome.
在本病例系列中，我们报告了4例患有唐氏综合征且症状与强迫症相符的患者。每位患者单独使用选择性5-羟色胺再摄取抑制剂（SSRI）进行药物治疗，或在SSRI治疗中加用利培酮后，强迫行为均有显著减少。所有患者均未出现明显副作用。这个小型病例系列支持使用这些药物治疗唐氏综合征患者合并的强迫症。
