通过钯催化的分子内杂环化反应构建多环吲哚骨架的新方法。

A new entry to polycyclic indole skeletons via palladium-catalyzed intramolecular heteroannulation.

作者信息

Liu Jianxiu, Shen Ming, Zhang Yongda, Li Guisheng, Khodabocus Ahmad, Rodriguez Sonia, Qu Bo, Farina Vittorio, Senanayake Chris H, Lu Bruce Z

机构信息

Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., 800 East Leigh Street, Suite 205, Richmond, Virginia 23219, USA.

出版信息

Org Lett. 2006 Aug 3;8(16):3573-5. doi: 10.1021/ol061440j.

DOI:10.1021/ol061440j

PMID:16869663

Abstract

[reaction: see text] A one-step method was developed for elaboration of a variety of polycyclic indole skeletons via a novel palladium-catalyzed intramolecular indolization of 2-chloroanilines bearing tethered acetylenes. This novel intramolecular indolization method unveils an unusual syn amidopalladation pathway of a tethered alkyne.

摘要

[反应：见正文] 开发了一种一步法，通过新型钯催化的带有连接乙炔的2-氯苯胺的分子内吲哚化反应来合成多种多环吲哚骨架。这种新型的分子内吲哚化方法揭示了连接炔烃的一种不寻常的顺式酰胺钯化途径。