Tsukamoto Hirokazu, Kondo Yoshinori
Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki-aza aoba 6-3, Aoba-ku, Sendai 980-8578, Japan.
Org Lett. 2007 Oct 11;9(21):4227-30. doi: 10.1021/ol701776m. Epub 2007 Sep 15.
Palladium(II) catalyzes annulation of internal alkynes with methyl 2-boronobenzoate and (2-boronophenyl)acetate to provide 2,3-disubstituted indenones and 3,4-disubstituted 2-naphthols, respectively. The annulation reaction would proceed through transmetalation of Pd(II) with the boron reagents and insertion of the alkynes, followed by unprecedented 1,2-addition of the generated alkenylpalladium(II) species to the intramolecular ester group.
钯（II）催化内炔烃与2-硼苯甲酸甲酯和（2-硼苯基）乙酸甲酯进行环化反应，分别生成2,3-二取代茚满二酮和3,4-二取代2-萘酚。该环化反应通过钯（II）与硼试剂的转金属化以及炔烃的插入反应进行，随后生成的烯基钯（II）物种对分子内酯基进行前所未有的1,2-加成。
