El-Mofty Medhat, Mostafa Wedad, Youssef Randa, El-Fangary Mona, Elramly Amany Z, Mahgoub Doaa, Fawzy Marwa
Phototherapy Unit Kasr El-Eini, Faculty of Medicine, Cairo University, Cairo, Egypt.
Photodermatol Photoimmunol Photomed. 2006 Aug;22(4):214-6. doi: 10.1111/j.1600-0781.2006.00229.x.
Both types of Ultraviolet (UV), UVB (290-320 nm) and UVA (320-400 nm), produce increased pigmentation or tanning. However, no evaluation of UVA alone in the treatment of vitiligo has been reported. Therefore, it was the purpose of this work to study the pigmentogenic effect of UVA (5 and 15 J/cm(2)) in vitiligo. The study included 20 randomly selected patients with vitiligo involving more than 30% of the body surface area with a bilateral/symmetrical distribution. They were equally divided into two groups each of 10 patients. All patients received three weekly sessions of UVA, 15 J/cm(2) in group I and 5 J/cm(2) in group II, a total of 48 sessions over 16 weeks. Overall pigmentation of 60% and above was recorded in 50% and 10% of patients in groups I and II, respectively. We conclude that broadband UVA alone, without psoralens, and in appropriate doses may be of important therapeutic value in vitiligo.
紫外线（UV）的两种类型，UVB（290 - 320纳米）和UVA（320 - 400纳米），都会导致色素沉着增加或晒黑。然而，尚无关于单独使用UVA治疗白癜风的评估报告。因此，本研究旨在探讨UVA（5和15焦耳/平方厘米）对白癜风的色素生成作用。该研究纳入了20例随机选择的白癜风患者，其白癜风累及超过30%的体表面积，且呈双侧/对称分布。他们被平均分为两组，每组10例患者。所有患者每周接受三次UVA照射，第一组为15焦耳/平方厘米，第二组为5焦耳/平方厘米，在16周内共照射48次。第一组和第二组分别有50%和10%的患者色素沉着达到60%及以上。我们得出结论，单独使用宽带UVA，不使用补骨脂素，且剂量合适，可能对白癜风具有重要的治疗价值。
